Hygiene

Homocysteine ​​when planning pregnancy: why do we need analysis

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Homocysteine ​​is a substance that is formed in the human body from methionine, which is extremely important for carrying a healthy child. From this amino acid directly depends on the blood circulation in the placenta and the proper development of the baby.

In the female body, the level of homocysteine ​​is constantly increasing throughout life, and during pregnancy, on the contrary, decreases. The maximum decrease in blood concentration is noted in the first and third trimester. To make a healthy baby, it is necessary to control homocysteine ​​when planning pregnancy.

Concept of norm

This substance is produced in the human body from various products rich in methionine. For example, milk, eggs, meat. In order to get pregnant safely, the level of amino acids should not exceed 11 µmol per milliliter of blood.

Find out whether the indicators are normal, better at the planning stage. This will allow:

  1. In case of insufficient level, adjust the diet according to the doctor's recommendation (enter foods rich in vitamins of group B into the menu). Also, special drugs may be prescribed that will allow the future mother's body to return to normal very quickly.
  2. To prevent miscarriage or abnormal development of the baby in the womb. After all, it is always easier to provide the conditions under which the placenta will function normally than subsequently to fight for the correct placental circulation.
  3. Determine whether the norm corresponds to the indicators typical for a completely healthy person. In pregnancy, the analysis may show unreliable numbers.

How is the analysis carried out

For an analysis to be reliable, a woman needs to properly prepare for it. All the details of the preparation is explained by the doctor. He should prescribe an immunochemiluminescent blood test taken from a vein and give all the necessary recommendations.

It is necessary to pass this test three months before the planned conception. If the history has already had problems with the level of amino acids, the analysis is carried out six months before conception.

Preparation for blood sampling requires:

  • do not smoke for half an hour before visiting the medical office,
  • do not eat for eight hours (it is allowed to drink only clean water without gas),
  • day not to overload yourself with physical work and sports training,
  • day do not eat fatty foods.

The laboratory will prepare the results in about two days. According to the answer, it will be possible to clearly and reliably determine whether the amino acid is produced in sufficient quantity or whether drug support and nutrition adjustment is required.

High level

If the level of homocysteine ​​in pregnancy is elevated, do not panic ahead of time. Probably, the test results were distorted or there are reasons to be eliminated.

For example, overestimation of the norm provokes:

  1. Lack of adequate physical exertion. Sitting work and a sedentary lifestyle does not have the best effect on the female body! To get rid of the problem, it is necessary to provide moderate exercise. Excellent swimming, skiing and cycling.
  2. Abuse of alcoholic beverages. Women can not drink them at least three months before the onset of pregnancy!
  3. Excessive use of coffee. This drink, alas, also does not add health.
  4. Smoking is another bad habit that directly affects the ability to become pregnant. The doctor will recommend to completely give up cigarettes.
  5. Unbalanced nutrition. Most often, future mothers do not get enough vitamins of group B (thiamine, folic acid, pyridoxine and cobalamin - that is, B1, B6, B9 and B12). To exclude vitamin starvation, the menu should include: cod liver, eggs, caviar, cottage cheese, cheeses, lean meat, beef liver, walnuts, greens, citrus. How to eat during pregnancy by month we described in this article.

It is necessary to eliminate all these factors and re-donate blood from a vein. If the analysis is confirmed, the doctor will prescribe treatment. Listen to the information where the doctor talks about the effects of hemocysteine, and how smoking can affect the rate of this substance in the body of a pregnant woman:

  • subcutaneous administration of B vitamins,
  • intake of aspirin in small doses and preparations of the heparin series (Cetroparin, Fragmin, Lovenox, and others).

The treatment is carried out under the constant supervision of the attending physician. Changing the dosage of drugs alone is strictly prohibited.

Low level

Too critical deviation from the norm (about 4 units) in the direction of reduction leads to poor health of the woman. A doctor in such a situation may advise to reduce physical exertion and even drink coffee in the morning. To determine the rate, the following table will help:

It should be noted that exceeding the norm is a great danger. With an increase of 2 units, the level of homocysteine ​​leads to impaired blood flow to the placenta - the baby does not receive enough oxygen and nutrients. As a result, there is a sharp slowdown in development. Miscarriages or fetal death may occur.

But the reduced level does not affect the vaginability and intrauterine development of the baby. Only the woman will suffer. She may feel weakness and fatigue during pregnancy. To correct such an unpleasant situation will help the correct mode of the day with long breaks for rest, walks, a balanced menu and a long sleep.

To exclude fetal death, it is necessary to consult a doctor six months before the onset of pregnancy, undergo an examination and pass all tests, including homocysteine. The doctor will tell you how to bring the body back to normal. A woman can only strictly follow medical prescriptions and then the pregnancy will pass without any health problems.

Homocysteine ​​when planning pregnancy: the norm and features

Let's not delve into complex chemical processes: let's just say that a person receives this amino acid as a result of processing consumed food. Before starting the planning of the child, the rate should be from 10 to 11 µmol / ml. Why do you need to check this figure before trying to conceive:

  1. In a pregnant woman, the amino acid level will be reduced: this is considered normal, but on condition that the decrease started from a natural indicator. If it has already been lowered / raised, a change in the waiting period of the child may become critical.
  2. If the results showed a non-compliance with the norm, no action was taken and conception took place - there is a big risk of circulatory disturbance in the placenta. This will directly affect the formation of the fetus and its prenatal development.
  3. The detected inconsistency can be corrected: the doctor will recommend a special menu and diet, sometimes even prescribe medications. Later analysis will need to be repeated. It is important to bring the value to the norm, and only after that to plan the child.

It is necessary to take an analysis (for it blood is taken from a vein) in the direction of a doctor, 3-6 months before the planned conception. If you have previously had problems with the level of this amino acid, it is better to diagnose in advance.

24 hours before delivery, you cannot go to the gym and work hard, there is a fat one. You can not eat 8 hours before the diagnosis. Allowed to drink, but only plain water. You can not smoke at least 30 minutes before the analysis.

Every future mother should check homocysteine ​​when planning pregnancy. This way she will relieve herself of many problems while expecting a child.

Deviations from the norm: what to do

The most dangerous indicator - the excess amino acid levels. Finding this, the doctor will try to find the cause. The most obvious factors are:

  • a lack of vitamins of group B - a diet will be prescribed to compensate for it, and in a catastrophic situation, intramuscular vitamin injections,
  • a lot of coffee in the diet of women - respectively, will have to limit or abandon it,
  • drinking alcohol - it is better to give up any drinks of this kind at least 3 months before conception,
  • smoking - directly affects the content of amino acids, so the habit is better to give up altogether, and long before pregnancy,
  • hypodynamia - if physical activity is not enough, moderate athletic loads will be assigned.

Exceeding the amino acid content is a direct path to premature birth or even the death of a child.

But the reduced level does not have a critical effect - but only if the indicator is not lower than 4.1 μmol / ml. When a critical level is reached, a woman should rest more, and 1 cup of coffee is allowed in the morning.

Be sure to check homocysteine ​​when planning a pregnancy - this is critically important if you are at risk: eat the wrong diet or have bad habits.

How to take the analysis and how to prepare for it?

For maximum accuracy of the analysis for homocysteine, it is necessary to conduct special preparatory actions. The material for the study is serum.

The procedure is carried out by the standard method - the blood from the patient is taken from a vein. Laboratory study of the material should occur within two hours after collection.

Preparatory actions to be carried out during the day before the analysis:

Norm homocysteine ​​when planning pregnancy

The norm of homocysteine ​​for women is an indicator from 4.6 to 12.44 μmol / L. Under the influence of some factors, the level of amino acids may decrease or increase. In some cases, changes in indicators are considered an alarm. You can decipher the test results yourself or with the help of a specialist.

Elevated homocysteine ​​when planning pregnancy

Numerous factors can provoke an increase in the level of amino acids in the blood, including not only external influences, but also progressive diseases of the internal organs. The reasons for the increase in homocysteine ​​are detected by exclusion or additional examination by specialized specialists.

The most common causes of increased homocysteine ​​are malnutrition, abuse of bad habits and a significant lack of vitamins in the body. If the analysis showed high homocysteine, after identifying its cause, the doctor recommends eliminating harmful factors and repeating the test procedure after a certain time.

The reasons for the increased content of amino acids can be the following factors:

    genetic disorders

What is homocysteine?

With protein food, methionine, one of the essential amino acids, enters the human body. As a result of processing the protein from methionine, homocysteine ​​is synthesized - its by-product.

It is also an amino acid, but, unlike methionine, it is impossible to obtain it with products. Methionine is an important component of metabolism and is found in large quantities in meat, dairy products and eggs. Especially a lot of it in the cottage cheese.

Normally, homocysteine ​​is found in the body in very small quantities. An important role in the metabolism of homocysteine ​​is played by the B vitamins and folic acid.

If these substances for processing are not enough, then the level of homocysteine ​​increases. In this case, the body triggers defense mechanisms and releases it into the blood in large doses.

Increasing the level of this amino acid leads to a weakening of the walls of blood vessels and as a result, the development of atherosclerosis, the formation of blood clots. Elderly people are at increased risk of developing Alzheimer's disease and age-related encephalopathy.

Elevated homocysteine ​​during pregnancy can lead to fetal death, and in people with diabetes, the risk of vascular complications increases.

Norms homocysteine ​​in the blood

In the study of the level of homocysteine ​​in the blood is considered the norm:

  • in men: 5.9–16.0 µmol / l,
  • in women: 3.4–20.4 µmol / L.

However, the listed norms are not so unambiguous. In women, the rate of homocysteine ​​during pregnancy is somewhat different from the standard. In future moms, the range of 4.6–12.4 µmol / l is considered optimal.

In children, homocysteine ​​is about 5 µmol / L regardless of gender. With the beginning of the process of puberty, the indicators first increase to 6–7 and then to 10–11 µmol / l, and the increase in homocysteine ​​in boys is more pronounced than in girls.

At about the same level, it remains in adults, but gradually increases with age.

The level of homocysteine ​​during pregnancy and its planning

As noted, the level of homocysteine ​​during pregnancy may be slightly different from the usual, and even go beyond the generally accepted framework.

In the first weeks of pregnancy, the level of this amino acid may be at the lower boundary of the specified range and, in this case, it is considered the absolute norm.

Also, reduced homocysteine ​​during pregnancy can be observed at the beginning of the 2nd trimester, which should also not cause concern. His level will finally return to the previous framework within a few days after birth.

However, the fact that the permissible deviation from the norm should not exceed 0.5 µmol / l is important, otherwise an urgent consultation of the observing gynecologist and therapist is necessary.

It is important to eat rationally and properly, carrying a baby. This is not only a guarantee of health and full development of the unborn child, but also a guarantee of maintaining the balance of important substances in the body, such as homocysteine. Read More: Pregnant Diet →

Women who are seen by a gynecologist during pregnancy are prescribed B vitamins and folic acid in prophylactic doses. These substances have a beneficial effect on the breakdown of homocysteine ​​and its normal level.

Since the body spends a lot of resources during pregnancy, such prophylaxis is an additional protection against increasing the level of amino acids.

Before you get pregnant, the most appropriate decision will be to be examined, including taking a blood test. When deviations from the norm, before you conceive a child, it is best to drink a course of vitamins, which should appoint a doctor.

In addition, to normalize the level of this substance, it is necessary to stop smoking and drinking coffee in large quantities. Homocysteine ​​when planning pregnancy is an important indicator that affects both the possibility of conception and gestation.

Who needs to be tested for homocysteine?

According to statistics found in recent studies, 30% of the adult population of the planet has more than doubled the level of homocysteine.

The following people need to pay attention to the level of this substance in the blood and from time to time tests for its content:

  • the elderly (over 60 years old),
  • people after surgery on the digestive tract,
  • people with thrombosis and vascular and heart diseases,
  • people with diabetes
  • people suffering from diseases of the thyroid gland and the endocrine system,
  • patients with renal failure,
  • persons with alcohol and drug addiction.

Separately, it is necessary to mention people who have a number of hereditary diseases associated with the production of enzymes.

It is also necessary to regularly test for homocysteine ​​during pregnancy, especially if previous births were aggravated. Women who have had preeclampsia during pregnancy should observe the level of homocysteine ​​in everyday life.

Causes of increased homocysteine, effects and treatment

Hyperhomocysteinemia - high levels of homocysteine ​​in the blood can be caused by a number of reasons. This is a hereditary factor, and some diseases, and the wrong way of life.

The most common causes of hyperhomocysteinemia are as follows:

  • heredity,
  • avitaminosis,
  • hormonal diseases, disorders of the kidneys and thyroid gland,
  • lack of exercise,
  • smoking, alcohol and drug use,
  • taking some drugs.

An inherited disorder that causes an increase in homocysteine ​​is homocystinuria. This is a metabolic defect caused by genetic predisposition.

With the disease, the absorption of certain amino acids, in particular methionine, is disturbed, which leads not only to jumps in the level of homocysteine ​​and other substances in the blood, but also to dysfunction of the central nervous system, heart and joints.

With avitaminosis, namely lack of vitamins of group B and folic acid, hyperhomocysteinemia also often occurs. In this case, it is treated with a simple intake of vitamins prescribed by a doctor.

Improper diet, sedentary lifestyle and bad habits violate the metabolic process, due to which there is an untimely splitting of homocysteine ​​and, accordingly, its increase.

To normalize the condition you need to give up alcohol and smoking, go in for sports and review the diet.

A common cause of the violation may be taking medications. Medicines for the treatment of psoriasis neutralize the action of folic acid, and anticonvulsant and immunosuppressive (for the treatment of autoimmune diseases) agents break down vitamin B in the body.

Именно их недостаток и приводит к нарушению. Также влияют на гомоцистеин некоторые антидепрессанты.

Последствия повышения уровня этой аминокислоты могут быть серьезными. В первую очередь это касается сосудов, поскольку гомоцистеин ослабляет их стенки.

The effects of hyperhomocysteinemia include:

  • thrombosis and atherosclerosis,
  • dementia and Alzheimer's disease in the elderly,
  • heart failure and myocardial infarction.

If homocysteine ​​is elevated during pregnancy, then this is a reason to start emergency treatment under the strict supervision of a gynecologist.

Excessive substance extremely negatively affects the fetus and can lead to serious developmental disorders or to its death. In the second half of pregnancy, preeclampsia (preeclampsia) or eclampsia can develop - a dangerous pathology that threatens the life of the mother and child.

Homocysteine ​​lowering: causes and effects

Low levels of homocysteine ​​in the blood may indicate pregnancy. In this case, not too much lower is the norm.

Another cause is multiple sclerosis. Often, this indicator in the blood test becomes the first “bell” about the onset of the disease. The diagnosis is made according to the results of additional studies.

If homocysteine ​​is lowered too much during pregnancy, one should not worry anyway. To bring his figure back to normal is not so difficult, for this you need to eat right and do not forget about moderate physical activity.

For future mothers are perfect walking in the fresh air or swimming. Another “medicine” with low homocysteine ​​is a cup of quality coffee in the morning.

Violations in the content of homocysteine ​​are easily amenable to correction and are most often treated in simple ways.

Reception of multivitamins, moderate sport and proper nutrition - three whales to normalize its level. But it is important to understand that any correction of indicators of blood tests should be carried out exclusively by the attending physician.

Author: Irina Maslova,
specifically for Mama66.ru

general description

Homocysteine ​​is an amino acid that is produced in the body from methionine. In turn, this substance enters the body with food. In children, the level of this amino acid is lower than in adults, and this is the physiological norm. With the onset of puberty, the level of homocysteine ​​increases.

The connection between homocysteine ​​and pregnancy is the most direct. In the normal course of pregnancy, the level of amino acid content becomes lower. This is necessary in order not to impair blood circulation in the placenta. In that case, if the level is significantly higher than the norm, then there may be serious problems with the vessels. In the most severe cases, elevated homocysteine ​​can cause fetal death.

Therefore, it is important to make appropriate analyzes during the planning period. If an increased level of homocysteine ​​is detected, measures should be taken in advance in order to reduce this figure. This is important because the formation and development of the fetus depends on normal blood circulation.

Tip! When a deficiency or excess of homocysteine ​​is detected, its level is adjusted by a special diet, rejection of bad habits and taking special preparations. Subsequently, it will be necessary to control homocysteine ​​during pregnancy in order to take action in a timely manner when detecting abnormalities.

How to conduct the analysis?

Experts recommend that women undergo a survey and find out the level of homocysteine ​​three months before the proposed ovary.

And if there were already problems with the content of this substance (for example, during a previous pregnancy), then samples should be taken six months before the start of planning.

Training

The rules for preparing for the analysis are quite simple:

  • at least one day you must abandon fatty foods and alcohol,
  • on the eve of the need to eliminate intense physical exertion, it is worth refusing to visit the gym,
  • sampling is done in the morning, you should refrain from eating for 8-14 hours before the procedure. It is allowed to drink only plain, non-carbonated water (tea, coffee is not allowed),
  • at least half an hour before sampling to give up smoking.

Rates and deviations

If as a result of the survey it is found that homocysteine ​​is contained in the amount of 10-11 μmol / l, then you can calm down, this is the physiological norm. If all other indicators are in order, you can safely plan a pregnancy. In the event that the obtained indicators differ significantly from the norm, it is necessary to take measures.

Reduced level

If the amino acid content is lowered slightly, there is no cause for alarm. Since reduced homocysteine ​​can not adversely affect the conception and subsequent gestation.

But if the level of amino acid content is too low (lower than 4.1 μmol / l), then it is necessary to take measures, otherwise it may affect the condition of the woman after the onset of pregnancy.

Tip! To increase the concentration of homocysteine ​​is to reduce the intensity of physical activity and drink coffee in the morning.

Elevated level

If the lowered homocysteine ​​content is rarely a concern of the physician, then with an increase in the content of this amino acid, measures will need to be taken even before conception.

First of all, the doctor will begin to look for the cause of the increased levels of the substance, and then recommend a treatment regimen to make the value of this indicator lower. Here are the main factors leading to increased homocysteine ​​concentrations:

  • Vitamin B deficiency. In this case, to make the figures lower, the doctor will recommend a diet high in thiamine, folic acid, pyridoxine, and other B vitamins. In addition, vitamins can be prescribed as tablets or injections.
  • Nicotine. Smoking, including passive, must be given up to both spouses planning to conceive a child.

  • Caffeine. It is necessary to reduce the consumption of products with the content of this substance, it is not only coffee, but also energy drinks.
  • Alcohol. Drinking beverages containing even a small percentage of alcohol should be excluded for the planning period, pregnancy and subsequent feeding,
  • Low level of physical activity. In order to make the level of homocysteine ​​lower it is worth doing physical exercise. It is necessary to walk more, sign up for the pool, buy a bicycle, etc.

Tip! Since the level of homocysteine ​​and normal pregnancy is a close relationship, you should not start planning until the content of the specified amino acid is normalized.

High homocysteine ​​during pregnancy is a risk to the fetus. Therefore, it is necessary to pass tests before planning to determine the concentration of this amino acid in the blood. With significant deviations from the norm, you must first take steps to normalize the content of homocysteine.

Effects

First of all, the child may develop oxygen starvation, which is a great danger for the growing fetus. Such changes can not lead to circulatory disorders in the placenta. The brain of a child may suffer irreversibly and the child will eventually die. At a later period, premature labor may occur in a woman, and the child will be born with a lag in weight and height. Therefore, pregnancy with an elevated level of homocysteine ​​is under the special control of gynecologists.

Women who have hypothyroidism and vitamin B1, B12, and B9 deficiencies are at risk. Impair the level of homocysteine ​​can kidney disease, psoriasis, diabetes. Significantly change the level of the content of this amino acid in the body can some drugs.

The only reason for which it is considered possible to deviate from the established norms, are genetic abnormalities. Preliminary diagnosis of homocysteine ​​levels is very important, as it is always possible to raise or lower the level of this substance.

Since for many women the result of the survey is very important, it is necessary to prepare for the examination very carefully. Together with the analysis of the level of this amino acid, the level of thyroid hormones is analyzed, the level of blood enzymes, the level of hemostasis, and the content of autoimmune antibodies are analyzed.

Eight hours before the analysis, you should exclude fatty foods from the diet. During these hours of training can not be actively engaged in physical activity. If you do not comply with these conditions, you can greatly distort the results. As a result, the doctor will develop the wrong tactics of pregnancy.

With a strongly elevated level of homocysteine, a course of vitamin therapy is prescribed. At the same time vitamins of group B are shown. Moreover, pregnant vitamins are mainly administered intramuscularly. With the active administration of drugs in this group, the risk of blood clots is high, so anticoagulants, for example, aspirin and drugs containing heparin, are also prescribed in parallel.

If you need to increase the level of amino acids, doctors advise to increase the rate of consumption of coffee. At the same time it is necessary to reduce their physical activity. If the level of homocysteine ​​decreases slightly before conceiving a child, the chances of conceiving and giving birth to a healthy baby are still high.

If you need to reduce the level of amino acids, you must stop drinking coffee, give up alcohol and cigarettes. It is recommended to seriously review the diet of women. It is necessary to include more greens, vegetables and fruits, eat cottage cheese, cheese, eggs and other products with a high content of vitamins of group B. You need to abandon sports training associated with heavy physical exertion.

What is homocysteine, and why control over its content is so important for the future mother?

Together with food, each person receives a substance such as methionine, which in the process of decomposition gives sulfur and Homocysteine ​​- an amino acid that affects the work of various organs. In an ideally healthy person, excess homocysteine ​​is neutralized with the help of certain enzymes. However, if their production in the body is impaired, then this can lead to an excess of amino acids, which, in turn, is very often one of the causes of premature birth. In turn, the lack of homocysteine ​​in the body of the future mother adversely affects her well-being. In addition, low levels of this amino acid often lead to a weakening of vital functions in the child's body - the baby can be born with congenital malformations, too low body mass, and various physical defects.

Homocysteine ​​levels during pregnancy: what should I look for?

Until puberty, both in boys and girls, the indicators of the content of this amino acid are approximately at the same level. In the process of the formation and development of the reproductive system, future mothers are accompanied by serious changes in the body, one of which is an increase in homocysteine. It is believed that after the start of the menstrual cycle, the rate of its content in the order of 10 µmol / ml.

A woman planning a pregnancy should be aware that optimal indicators of homocysteine ​​in the body at conception should be about 8-9 micromol / ml. In this case, after the onset of pregnancy, they are somewhat reduced, which is the norm. In the first and last trimesters, the amount of homocysteine ​​in the mother’s blood should fluctuate between 5–8 µmol / ml. In the second trimester, the level of amino acids increases slightly and can reach up to 9-10 μmol / ml. However, just a few days after giving birth, these figures increase slightly to a level that was normal for a woman before the onset of pregnancy.

How to adjust the level of homocysteine ​​yourself?

Nowadays there are quite a lot of all sorts of drugs that help to cope with such deviations. If the level of homocysteine ​​is too high, expectant mothers are prescribed a course of treatment with B vitamins, which include folic acid. It promotes the development of enzymes, which, in turn, are responsible for regulating the level of this amino acid.

However, the expectant mother can take care of her own health if she understands a few simple rules. Elevated levels of homocysteine ​​in her body can be associated with malnutrition, when too much protein is present in the diet. By limiting intake of meat, eggs and milk, it is possible to adjust the indicators of the content of this amino acid in the blood without medicines. In addition, it should be remembered that smoking, drinking alcohol, stress and the abuse of coffee can lead to inhibition of the production of enzymes involved in the breakdown of homocysteine. For this reason, during pregnancy, bad habits should be abandoned.

The low level of homocysteine ​​in the blood is an excellent reason to strengthen the diet, supplementing it with meat and dairy products. In addition, expectant mothers should spend as much time as possible in the fresh air, keep an active lifestyle, if possible, and avoid stressful situations.

The formation of homocysteine ​​in the body

This substance does not enter the body through eating, but is produced independently from the essential amino acid - methionine. Methionine is a structural element that enters the body with food. It is found in dairy and meat products.

Homocysteine ​​is formed due to the biosynthesis of methionine under the influence of ATP and various enzymes. The sequence of biochemical processes in the body contributes to sufficient production of homocysteine, the level of which does not pose a threat to health.

High homocysteine ​​affects the functioning of the cardiovascular system and can cause atherosclerosis and other diseases.

Homocysteine ​​level at pregnancy planning stage

It is necessary to diagnose homocysteine ​​in the blood when planning pregnancy. This will help avoid possible complications with gestation, eliminate the likelihood of developmental defects in the fetus. Regular biochemical blood tests will help control homocysteine.

When planning a pregnancy, it is much easier to undergo a therapeutic course of treatment without harming the child. In addition, a healthy mother is much more likely to bear and give birth to a healthy baby.

At the border between the first and second trimesters of pregnancy, the level of homocysteine ​​can slightly decrease, which provides improved blood circulation and an adequate supply of placenta with oxygen.

During pregnancy, the amount of a component such as homocysteine ​​in the blood can vary considerably. The pregnancy rate ranges from 4.6 to 12.4 µmol / L. Deviation from these indicators requires immediate intervention by doctors.

What affects the level of homocysteine

Many factors can influence the homocysteine ​​index (alcohol, smoking, sedentary lifestyle, intake of coffee in large quantities, use of certain drugs, including those containing methionine). All of them can contribute to the fact that homocysteine ​​is formed in excess in blood.

What does it mean? Elevated levels of homocysteine ​​adversely affect the state of the inner walls of blood vessels. This substance is toxic, with an excess in the blood contributes to the formation of deposits inside the vessels, and accordingly, their blockage. Due to the formation of thrombosis hyperhomocysteinemia develops.

Another reason for the increase in homocysteine ​​is the lack of vitamins (in particular, folic acid and vitamins of group B) and the presence of diseases such as diabetes mellitus, psoriasis, disorders in the thyroid gland.

Symptoms of hyperhomocysteinemia

Changes in the level of homocysteine ​​in pregnant women are also associated with the restructuring of the body and its subsequent preparation for labor. This increases blood clotting to prevent large blood loss during childbirth.

When homocysteine ​​is elevated, blood clots faster, in women with thrombophilia, blood clots may form in the vessels. Therefore, it is necessary to maintain the substance in the norm, to prevent blockage of blood vessels and hypoxia in the fetus.

The most common symptoms of high homocysteine ​​are pain in the legs. There may be convulsions, especially often at night, a feeling of fullness in the area of ​​the gastrocnemius muscle.

Diagnosis of homocysteine

Homocysteine ​​during pregnancy is diagnosed by a biochemical blood test, which is taken from a vein. Before the analysis it is worth observing some points: do not resort to alcohol, avoid physical exertion and follow a diet.

It is forbidden to take food on the day of testing. Blood tests will be performed within two days, after which the results can be considered reliable.

There is another way to diagnose, when a woman takes food containing methionine before taking blood. After determining the elevated level of the substance, it is necessary to conduct a test, the result of which will be a refutation or confirmation of the onset of the development of obstetric or cardiovascular diseases.

Treatment of hyperhomocysteinemia

The course of treatment should be prescribed by the physician, taking into account the results of the biochemical blood test and the possible reasons due to which hyperhomocysteinemia has developed. Первоначальным способом нормализации уровня гомоцистеина является внутримышечное введение витаминов группы В.

Существуют специальные адаптированные витаминные препараты для беременных, которые позволяют стабилизировать и привести в норму гомоцистеин. What could it be? Since the most frequent cause is a lack of vitamins during pregnancy, therefore, treatment is prescribed to take vitamin complexes containing folic acid and vitamins of group B.

In addition to vitamin preparations, it is possible to prescribe anticoagulants. They will help prevent the formation of blood clots and reduce blood clotting.

Hyperhomocysteinemia with timely diagnosis is easily treated and does not harm the health of the fetus and mother. While neglect of treatment can provoke the development of infertility and miscarriage.

Homocysteine ​​is higher than normal, influence when planning, and at B

My first pregnancy is normal. The second ST (October 5, 2014) is for a period of 6 weeks (it came out on week 7, after a day when I found out, then we cleaned it up a little). I decided to be examined, I passed all sex hormones (by cycle days at the beginning and after ovulation (I followed ovulation by folliculometry)), thyroid hormones, extended coagulogram, plus antiphospholipid syndrome, homocysteine, dimer, antispermal bodies, hCG antibodies, el-p-test mutations of the hemostasis system (11 indicators), ultrasound at the beginning and in the middle of the cycle.

Bottom line: everything is normal, except for elevated homocysteine ​​at 18.7 at normal (4-12). Well, and mutations of genes responsible for the assimilation of folk.

The gynecologist prescribed to drink (before and during time B) chimes every 10 days, 3 tablets per day, and vitamins, http://www.baby.ru/pharmacy/12958-angiovit/ 1 tablet per day, and fembion 1 to 1 a pill a day.

Gynecologist allowed to change, because homocysteine ​​is not so bad.

Are these medicines enough? How did you lower homocysteine, in what dosages? How then was taken out and given birth?

Homocysteine ​​during pregnancy

You have elevated homocysteine ​​- a woman can hear such a diagnosis when carrying a child. But one who is far from biology and chemistry is unlikely to figure out what kind of substance it is. However, we will try to shed some light on this phenomenon.

Homocysteine ​​is a substance that is formed in the human body as a result of the processing of the amino acid methionine. In turn, methionine enters the body with food. By the way, the amino acids methionine are very useful, they are in meat, eggs and dairy products.

The norm of homocysteine ​​during pregnancy

The norm of homocysteine ​​in the blood for a pregnant woman is from 4.6 to 12.4 µmol / l (for comparison, the average norm of the concentration of homocysteine ​​in the blood of an adult is 10-11 µmol / l). Of course, some deviations are allowed, but not more than 0.5 µmol / l in each direction.

In case of an increased or, on the contrary, reduced level of homocysteine ​​in the expectant mother, it is necessary to consult a doctor for advice and be sure to treat the problem, because your health and your unborn child's health depends on it.

The level of homocysteine ​​throughout life is constantly changing. This is affected by a variety of factors, in particular the period of puberty. Pregnancy can also cause changes in the level of homocysteine ​​in the blood. In the early stages of its physiological decline.

Low Homocysteine

Some decrease in homocysteine ​​with the onset of pregnancy is not dangerous, because it is a normal reaction of the organism to changes occurring with it during this period. However, many people are interested in how a lowered homocysteine ​​affects pregnancy. You should know that this condition in women in the position in the early stages does not require any treatment. But sometimes a low level of homocysteine ​​can have a certain negative impact on the well-being of a pregnant woman.

There is a risk group, which doctors constantly advise to monitor the level of homocysteine ​​in the blood. For example, we are talking about women who plan to become a mother a second time, women are also at risk in the second and third trimester of pregnancy, if they have complications. In addition, an increase in homocysteine ​​levels may be associated with a genetic predisposition or some hereditary pathologies. Women at risk of thrombophilia are also at risk.

I have behind 2 ZB, I examined a lot. They determined the cause - scandal to thrombosis (thick blood), afs, tendency to folate deficiency. You have high homocysteine ​​can be the cause of failure. Did you give it at B or after it?

Natusya I was online 9 minutes ago

I had 3 ZBs (((and our first pregnancy was a daughter, the second and third were frozen, the fourth was born a son, the fifth was frozen, now the sixth is afraid (all B from one husband). I also donated hormones, everyone said it was an infection, but thank God they don’t find anything, now they say they don’t have enough hormones, give birth to a son on the hormones and now I’m sitting on them, they sent me to genetics but they said that since you have common children you don’t come to us ... In short, they play every time in daisy infuriates as much (

Anna I was online 26 April, 17:49 Russia, Moscow

Natusya, I hope that this time everything will work out. What are you drinking now? And how much time has passed, after the last ST?

Elena Berezovskaya2013 / 08/04, #

Continued 13: and in spite of everything). Tune in positively. Forget about your any sores! A child needs a mother who is ready to accept this child morally. It will not work, then we will discuss what to do next. But you need to believe in yourself. You get pregnant! You had a pregnancy. So what's the problem? The fact that you are looking for pregnancy outside your body and outside sexual relations, and through pills and procedures. This mistake makes so many women. As soon as they realize that nature has given them everything to have children, these children appear.

Analyzes before conceiving

It is important to track homocysteine ​​when planning a pregnancy. To do this, you need to visit a doctor and donate blood for analysis. This procedure is especially important for women who have already had problems with childbearing and delivery.

Before conception, the normal level of homocysteine ​​can be different, it depends on the age, weight and even the race of a woman (due to differences in metabolic processes). Therefore, the doctor will have to take into account all these factors and only then talk about the results of diagnosis.

In the first and third trimester, homocysteine ​​should decrease. The indicator in the analysis of blood can vary from 4.6 to 11 µmol / ml. If during the gestation period the amino acid content does not fall, but begins to grow, this is dangerous for the baby’s further development.

How to reduce homocysteine

To avoid adverse effects, it is necessary to pass tests before pregnancy and be regularly examined during gestation. This will allow you to control the level of homocysteine ​​and reduce it in time. For therapy purposes, the following approaches are used:

  • vitamin-mineral complexes with folic acid and vitamins of group B,
  • correction of nutrition, including the refusal of caffeine-containing beverages and foods, alcohol, fatty and salty foods,
  • a diet with an increased amount of greens, fresh vegetables, fruits, lean meat, fish, poultry, cereals,
  • tomato and pumpkin juice, nuts and dairy products - they quickly lead to normal homocysteine ​​levels,
  • comfortable physical activities (walking, gymnastics, swimming).

If the increase in the level of homocysteine ​​is triggered by some disease, for example, hypothyroidism or diabetes mellitus, then the main pathology is necessarily treated. After all, a violation of amino acid metabolism is only one of the symptoms that cannot be eliminated separately.

Not always the level of homocysteine ​​increases, sometimes you can observe its pathological decrease, which will negatively affect the formation of fetal muscle and epithelial tissues, provoking a delay in its growth. To increase the content of this amino acid, it is recommended to reduce the level of physical activity: more rest, sleep at least 7 hours a day, minimize the amount of animal protein in your diet. It is recommended to drink coffee or green tea, as well as chocolate, but not to overdo it, since an excess of caffeine can cause hypertension.

Pregnancy is the most crucial period in a woman’s life. To give birth to a healthy baby, you should carefully consider the preparation before conception: pass all the necessary tests, one of which will determine the level of homocysteine. This amino acid affects the development and gestation of the baby, so it is important to regularly monitor its amount in the blood and, if necessary, take measures in time.

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