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Logest for endometriosis

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Logest ® is a low-dose monophasic oral combined estrogen-progestin contraceptive drug.

Logest's contraceptive effect is accomplished through complementary mechanisms, the most important of which are the suppression of ovulation and changes in the state of the cervical mucus.

In women taking combined oral contraceptives, the cycle becomes more regular, the pain and intensity of menstrual-like bleeding decrease, reducing the risk of iron deficiency anemia. In addition, there is evidence that the risk of endometrial cancer and ovarian cancer is reduced.

If used correctly, the Pearl index (an indicator reflecting the pregnancy rate in 100 women during the year of using the contraceptive) is less than 1. If the tablets are misused, including by skipping the tablets, the Pearl index may increase.

Pharmacokinetics

Absorption. After ingestion, gestodene is quickly and completely absorbed, its maximum concentration in serum, equal to 3.5 ng / ml, is reached in approximately 1 hour. Bioavailability is approximately 99%. Distribution. Gestodene binds to serum albumin and sex hormone-binding globulin (SHBG). In free form is only about 1.3% of the total serum concentration, about 69% - specifically associated with SHBG. Induction of ethylene estradiol synthesis of SHBG affects the binding of gestodene to plasma proteins.

Metabolism. Gestodene is almost completely metabolized. Serum clearance is approximately 0.8 ml / min / kg.

Inference. The content of gestodene in serum undergoes a two-phase reduction. The elimination half-life in the terminal phase is about 12 hours. In unchanged form, gestodene is not excreted, but only in the form of metabolites, which are excreted by the kidneys and through the intestine in a ratio of about 6: 4 with a half-life of about 24 hours.

Equilibrium concentration. Gestodene pharmacokinetics are influenced by serum SHBG concentration. As a result of the daily intake of the drug, the concentration of the substance in the serum increases by about 4 times during the second half of the contraceptive cycle.

Absorption. After oral administration, ethinyl estradiol is rapidly and completely absorbed. The maximum serum concentration of approximately 65 pg / ml is reached in 1-2 hours. During absorption and "first pass" through the liver, ethinyl estradiol is metabolized, with the result that its bioavailability on ingestion is on average about 45%.

Distribution. Ethinyl estradiol is almost completely (approximately 98%), although not specific, bound by albumin. Ethinyl estradiol induces the synthesis of SHBG. The apparent volume of distribution of ethinyl estradiol is 2.8-8.6 l / kg. Metabolism. Ethinyl estradiol is subjected to presystemic conjugation, as in a thin mucosa. intestines and in the liver. The main metabolic pathway is aromatic hydroxylation. The rate of clearance from blood plasma is 2.3 -7 ml / min / kg.

Inference. The decrease in the concentration of ethinyl estradiol in the blood serum is biphasic, the first phase is characterized by a half-life of about 1 hour, the second - 10-20 hours. Unchanged from the body is not displayed. Ethinyl estradiol metabolites are excreted in urine and bile in a ratio of 4: 6 with a half-life of about 24 hours.

Equilibrium concentration. Equilibrium concentration is reached in approximately one week.

Release form, composition and packaging

Coated Tablets white color, round shape.

Excipients: lactose monohydrate - 37.155 mg, corn starch - 15.5 mg, polyvidone 25 000 - 1.7 mg, magnesium stearate - 550 μg, sucrose - 19.66 mg, polyvidone 700 000 - 171 μg, macrogol 6000 - 2.18 mg, calcium carbonate - 8.697 mg, talc - 4.242 mg, mountain glycolic wax - 50 µg.

21 pieces - blisters (1) - packs cardboard.
21 pieces - blisters (3) - packs cardboard.

Dosing regimen

Tablets should be taken orally in the order indicated on the packaging, every day at about the same time, with a small amount of water. Take one tablet per day continuously for 21 days. Receiving the next pack begins after a 7-day break in taking the pills, during which the withdrawal bleeding usually develops. Bleeding, as a rule, begins 2-3 days after taking the last pill and may not end before the start of taking a new pack.

How to start taking Logest

• In the absence of taking any hormonal contraceptives in the previous month.

Reception of Logest begins on the first day of the menstrual cycle (i.e., on the first day of menstrual bleeding), it is allowed to start at 2-5 menstrual periods, but in this case it is recommended to additionally use a barrier method of contraception during the first 7 days of taking the pills from the first package .

• When switching from other combined oral contraceptives, a vaginal ring or a contraceptive patch.

It is preferable to start taking Logest next day after taking the last hormone-containing tablet from the previous package, but in no case later than the next day after the usual 7-day break (for drugs containing 21 tablets) or after taking the last inactive tablet (for drugs containing 28 tablets per pack). Reception of Logest should be started on the day the vaginal ring or patch is removed, but no later than the day when a new ring is to be inserted or a new patch is pasted.

• When transferring from contraceptives containing only gestagens (mini-pili, injection forms, implant), or from a progestin-releasing intrauterine contraceptive (Mirena ®).

A woman can switch from a mini-drank to Logest any day (without a break), from an implant or an intrauterine contraceptive with a progestogen - on the day of its removal, from an injection form - from the day when the next injection should be made. In all cases, you must use an additional barrier method of contraception during the first 7 days of taking pills.

• After an abortion in the first trimester of pregnancy.

A woman can start taking the drug immediately. Subject to this condition, the woman does not need additional contraceptive protection.

• After childbirth or abortion in the second trimester of pregnancy.

It is recommended to start taking the drug on the 21-28 day after birth, if the woman does not breastfeed, or after an abortion in the second trimester of pregnancy. If reception is started later, you must use an additional barrier method of contraception during the first 7 days of taking the pills. However, if a woman has already had a sexual life, before the start of taking Logest, pregnancy should be excluded or it is necessary to wait for the first menstruation.

Taking missed pills

If the delay in taking the drug was less than 12 hours, contraceptive protection is not reduced. A woman should take a pill as soon as possible, the next one is taken at the usual time.

If the delay in taking the pills is more than 12 hours, contraceptive protection can be reduced. The more pills are missed, and the closer the pass to the 7-day break in taking pills, the greater the likelihood of pregnancy. In this case, you can follow the following two basic rules:

• The drug should never be interrupted for more than 7 days.

• 7 days of continuous intake of tablets are required to achieve adequate suppression of the hypothalamic-pituitary-ovarian regulation.

Accordingly, the following recommendations can be given if the delay in taking the pills was more than 12 hours (the interval from the moment of taking the last pill is more than 36 hours).

• First week of taking the drug

A woman should take the last missed pill as soon as she remembers (even if it means taking two pills at the same time). The next pill is taken at the usual time. Additionally, a barrier method of contraception (for example, a condom) should be used within the next 7 days. If sexual intercourse took place during the week before the pill is missed, the likelihood of pregnancy should be considered.

• The second week of taking the drug

A woman should take the last missed pill as soon as she remembers (even if it means taking two pills at the same time). The next pill is taken at the usual time.

Provided that the woman took the pills correctly within 7 days preceding the first missed pill, there is no need to use additional contraceptive measures. Otherwise, as well as skipping two or more pills, you must additionally use barrier methods of contraception (for example, a condom) for 7 days.

• The third week of taking the drug

The risk of reducing the reliability is inevitable due to the upcoming break in taking pills. A woman should strictly adhere to one of the following two options. Moreover, if in the 7 days preceding the first missed pill, all the pills were taken correctly, there is no need to use additional contraceptive methods.

1. A woman should take the last missed pill as soon as she remembers (even if it means taking two pills at the same time). The following tablets are taken at the usual time, until the tablets from the current packaging run out. The next pack should start right away. Bleeding "cancellation" is unlikely until the second package ends, but there may be spotting and "breakthrough" bleeding while taking pills.

2. A woman can also stop taking pills from the current pack. She should then take a break for 7 days, including the day she misses the pills, and then start taking a new pack.

If a woman misses taking pills, and then during a break in reception she has no withdrawal bleeding, it is necessary to exclude pregnancy.

Recommendations in case of vomiting and diarrhea

If the woman had vomiting or diarrhea within 4 hours after taking the pills, absorption may be incomplete and additional contraceptive measures should be taken. In these cases, you should focus on the recommendations when skipping pills.

Change the days of the onset of menstrual bleeding

In order to delay - the onset of menstrual bleeding, a woman should continue taking the pills from the new package of Logest immediately after all the pills from the previous one are taken, without interruption in the intake. Tablets from this new package can be taken as long as the woman wants (until the package is finished). While taking the drug from the second package, a woman may have spotting or "breakthrough" uterine bleeding. To resume taking Logest from a new pack should be after the usual 7-day break.

In order to postpone the day of the onset of menstrual bleeding to another day of the week, the woman should reduce the next break in taking the pills for as many days as she wants. The shorter the interval, the higher the risk that she will not have withdrawal bleeding, and further there will be spotting and “breakthrough” bleeding while taking the second package (just as if she would like to delay the onset of menstrual bleeding).

Additional information for specific patient groups

Elderly patients

Not applicable. The drug Logest is not shown after menopause.

Patients with hepatic impairment

The drug Logest contraindicated in women with severe liver disease as long as the indicators of liver function does not come back to normal. See also the section "Contraindications".

Patients with kidney impairment

The drug Logest was not specifically studied in patients with disorders of the kidneys. The available data do not imply correction of the dosage regimen in such patients.

Drug interactions

The interaction of oral contraceptives with other drugs can lead to breakthrough bleeding and / or decreased contraceptive efficacy. Women taking these drugs should temporarily use barrier methods of contraception in addition to Logest, or choose another method of contraception. The following types of interactions have been reported in the literature.

Effect on hepatic metabolism: the use of drugs that induce liver microsomal enzymes can lead to an increase in the clearance of sex hormones. These drugs include phenytoin, barbiturates, primidone, carbamazepine, rifampicin, and there are also suggestions for oxcarbazepine, topiramate, felbamate, griseofulvin, and preparations that contain St. John's wort.

HIV proteases (eg, ritonavir) and non-nucleoside reverse transcriptase inhibitors (eg, nevirapine), and combinations thereof, also have the potential to affect hepatic metabolism.

Effects on enterohepatic recirculation: According to individual studies, some antibiotics (for example, penicillins and tetracyclines) can reduce the enterohepatic recirculation of estrogens, thereby reducing the concentration of ethinyl estradiol.

During the taking of drugs that affect the microsomal liver enzymes, and within 28 days after their withdrawal, the barrier method of contraception should be additionally used.

During the reception of antibiotics (such as penicillins and tetracyclines) and within 7 days after their cancellation, you should additionally use a barrier method of contraception. If the period of use of the barrier method of contraception ends later than the tablets in the package, you need to proceed to the next package of Logest without the usual interruption in taking the pills.

Oral and combined contraceptives can affect the metabolism of other drugs, which leads to an increase (for example, cyclosporine) or a decrease (for example, lamotrigine), their concentration in plasma and tissues.

Side effect

When taking Logest, as well as other combined oral contraceptives, there may be irregular bleeding (spotting or "breakthrough" bleeding), especially during the first months of use. Against the background of taking combined oral contraceptives, women also had other undesirable effects, the connection of which with the use of drugs was not confirmed, but was not refuted.

Taking Logest, as well as other combined oral contraceptives, can reduce the amount of breast milk and change its composition, therefore, their use is not recommended during lactation. A small amount of sex hormones and / or their metabolites can be excreted in breast milk.

special instructions

If any of the conditions / diseases / risk factors listed below are present, then the potential risk and the expected benefits of using combined oral contraceptives, including Logest, in each individual case should be carefully weighed and discussed with the woman before , as she decides to start taking the drug / In case of aggravation, amplification or the first manifestation of any of these conditions or risk factors, the woman should consult with your obstetrician-gynecologist, who can decide Need to discontinue the drug.

Diseases of the cardiovascular system

Results of epidemiological studies indicate a relationship between the use of combined oral contraceptives and an increased incidence of venous and arterial thrombosis and thromboembolism (such as deep vein thrombosis, thromboembolism of the pulmonary artery, myocardial infarction, cerebrovascular disorders) when taking combined oral contraceptives. These diseases are rare.

The risk of venous thromboembolism (VTE) is maximum in the first year of taking such drugs. Increased risk is present after the initial use of combined oral contraceptives or the resumption of the use of the same or different combined oral contraceptives (after a break between taking the drug in 4 weeks or more). Data from a large prospective study involving 3 groups of patients show that this increased risk is present mainly during the first 3 months. General risk of VTE in patients taking low-dose combination oral contraceptives (Another 8 patient reviews

I have an ambiguous attitude towards this drug. Appointed because of the irregular cycle and facial hair. Saw on the recommendation of the gynecologist from the clinic. For acne, it helped, the cycle has been adjusted. But other problems started: migraine attacks became more frequent, veins appeared more noticeably, sexual desire decreased. The doctor canceled the drug. More weight has grown very much. I did not get this drug.

Врач прописал мне "Логест" для нормализации цикла и восстановления гормонального фона после родов. Никаких анализов, естественно, сделано не было. Пила препарат чуть больше года, а вот разочарования от него уже на 1,5. Поначалу всё было хорошо, но потом начались такие жуткие головные боли (просыпалась от них даже по ночам), полное отсутствие желания и постоянные перепады настроения. Конечно, свою основную функцию - предохранение от незапланированной беременности, препарат выполнял превосходно. It is a pity that he gave such results, and now I am recovering from his reception.

Took this drug for over a year. Prescribed to restore the cycle. The first months were nausea, then everything was fine. During his reception very thin. Absolutely lost libido. Replaced with other hormonal drugs.

I accept "Logest" for more than three months. My attending gynecologist prescribed him to me, to whom I have been referring for more than four years. This drug suits me, taking it, I noticed an improvement in my body. My hair stopped falling out, and now, after combing, there is almost no hair left in the comb. The nails also ceased to exfoliate, but the main thing is that menstruation is not as painful as before. I am pleased with this hormonal drug, but you should always consult with your doctor before starting to take such a hormonal drug. The doctor must choose for you what suits you, so that there are no consequences, but the drug is selected according to the results of the examination and the tests you passed.

Drink "Logest" for almost a year. There are no problems. Previously, when not drinking the drug, there were acne, painful and strong periods, which lasted a week. Now it is only three days and everything passes easily and painlessly. Acne disappeared. I even lost weight. Feel great. When I saw other contraceptives for 5 years, I also felt great. For me, this is the best method of contraception.

Logest appointed a doctor as a means of contraception, as well as level the cycle. She took it for several months, quit taking because there were constant discharge in the middle of the cycle. And now I think that hormonal drugs should be prescribed by a physician, after analyzing hormones.

The drug was recommended by the gynecologist for the restoration of hormonal levels after a frozen pregnancy as one of the best in its price category. After a month of use, hair began to fall out terribly, blood pressure jumped. Terrible fatigue was replaced by excitement and bouts of rage. I went to the regional center for examination, where the doctor was terrified and said - “Are you not going to give birth ?! Who assigned you to him? ” As it turned out - the drug is good, but does not go to me for planning a pregnancy. I was shocked. Logest canceled, appointed another hormone. My advice - be careful with hormonal drugs, require testing before the appointment!

I, as it turned out, did not fit. Saw for a long time, about 5 years - the gynecologist said that it is possible without taking breaks. There were no problems at first, but after a few years, the hair began to fall down actively. Trichologist said it because he does not suit me (the gynecologist appointed Logest without doing any tests), and if you drink OK for a long time, which are not right for you, then there will certainly be problems! But I repeat: not because they are bad, but poorly chosen. Now I drink Yarin. It seems the situation is improving. Of course, without Logest, there were plenty of problems, but he aggravated the situation.

Content

Logest is prescribed for endometriosis as a contraceptive drug. This disease requires hormone therapy, therefore logest is often recommended for treatment.

Endometriosis is a pathological disease in which endometrial cells grow outside the uterus. More often women of reproductive age from 20 to 45 suffer from it. There are many theories about the causes of this disease, but this question has not been fully studied.

Symptoms of endometriosis

Identify the main factors in the development of pathology:

  • Hormonal failure in the body, when one hormone exceeds another, so decreases the level of progesterone, which leads to disruption of the adrenal glands.
  • During menstruation, blood is thrown from the endometrium into the abdominal cavity, where the cells begin to expand. This leads to pathology.
  • Genetic heredity is one of the causes of the disease.
  • Reduced immunity leads to the fact that the body does not fight with endometrial cells outside the uterus. Therefore, cells take root and begin to grow.

Endometriosis arises from various factors: frequent abortions, inflammation of the female genital organs, the use of spirals, mechanical interventions.

This disease is considered one of the most mysterious in the field of gynecology. Sometimes this disease proceeds without symptoms, but there are cases when they are pronounced. It depends on the form and severity of endometriosis, on the presence of other gynecological diseases, and even on the psychological state of the woman.

Pain during menstruation, also during sexual intercourse with a partner. Especially pain is felt in the lower abdomen and lower back, it is of varying intensity.

Menstrual irregularities occur, menstruation becomes abundant, brown discharge appears before and after menstruation.

A woman may not know about the disease until she decides to become pregnant. Endometriosis is the main cause of infertility, since reproductive dysfunction occurs. Nausea and vomiting may occur, and body temperature rises.

There are four stages in the development of the disease. It is important not to aggravate the situation and start treatment at an early stage, then the result will come sooner.

Endometriosis treatment

An experienced gynecologist when examining a woman can make a preliminary diagnosis. But more accurate diagnosis will provide additional instrumental examination and testing.

When viewed on a gynecological chair, the doctor may feel a hardening and enlargement of the uterus. A woman needs an ultrasound scan to help identify ovarian cysts. Hysterosalpingography will assess the patency of the fallopian tubes and the extent of the spread of pathology

Endometriosis can be treated conservatively or surgically. But more often use the combined approach of treating the disease.

When the drug method is used hormone therapy.

COC - combined oral contraceptives:

These drugs must be taken continuously for at least six months. The exact duration of the course will be determined by the attending physician. Also use anti-inflammatory, painkillers and vitamins.

If conservative therapy does not bring positive changes, surgical intervention is prescribed. Often, the patient undergoes laparoscopy - this is a microoperation, which removes the affected lesions.

After surgery, hormones are prescribed, such treatment restores the fertility of the woman. But such patients should be monitored regularly by a doctor. After treatment, a woman can feel all the joys of motherhood.

Contraceptive drug Logest

This drug is considered very popular in modern medicine. It is often used to treat endometriosis. Logest has positive feedback from patients that he was accepted.

It helps to normalize the menstrual cycle, improves skin condition, is also used as a contraceptive.

Logest is a low-dose combined oral contraceptive that is prescribed for the prevention and treatment of gynecological female diseases. The main action of the contraceptive is considered to be changes in the properties of cervical mucus and suppression of ovulation.

Logest is important to use after consulting a doctor, strictly according to the instructions. You need to drink pills at the same time, not skipping every day. The action of the drug can reduce smoking and alcohol consumption.

Logest earned positive feedback from many experts. It is suitable for almost all patients, but has contraindications. You can not use such hormonal agents for pregnant and lactating mothers.

But it has side effects, so you need to consult a doctor before taking it. If nausea, vomiting occurs, it is better to stop taking pills and replace them with other contraceptives.

Logites reviews are different, often women complain of decreased libido, but this depends on the individuality of each patient.

Reviews of doctors and patients


Svetlana Nikolaevna, 32 years old

About Logeste heard only positive reviews, so she decided to try them. I want to note the improvement in the condition of the skin of the face, I was even younger. This drug helped me to regulate the menstrual cycle, also ceased to have pain during menstruation. Probably, my body lacked some hormone, and this drug helped restore it.

Stanislava Viktorovna, 29 years

I use these pills for five years. Everything suits me, the main thing is to comply with the prescription. I drink in the morning, at the same time, everything is indicated on the blister, so it’s impossible to confuse. The weight did not gain, only the chest increased slightly, which in principle is even good.

I found one wonderful action, you can make sure that your period is absent, immediately after the end of the package, to start another one without interruption. It is undesirable to abuse this, but during the holiday period it is very convenient.

Anastasia Yuryevna, 22 years

Logest attributed to me my doctor, I was not yet pregnant, so I was prescribed the most benign contraceptive, microdose. I had some minor problems with the female, I took the remedy for about a year, and regularly underwent a medical examination. I want to note, the inflammation has disappeared, the menstrual cycle has returned to normal. I had no side effects. Therefore, I was very pleased with this drug.


Antonina Alexandrovna, obstetrician-gynecologist

Contraceptive drug Logest, prescribed to women, not only to protect against unwanted pregnancy, but also as hormone therapy for gynecological diseases, such as endometriosis. It helps eliminate hormonal disorders, relieves pain, and prevents the recurrence of the disease. As a doctor, I recommended this remedy to many women and heard only positive reviews.

Evgeny Ivanovich, gynecologist

I want to note that these pills, like many others, have side effects, so a woman should definitely consult a doctor before taking it. Nausea may occur, libido decreases, blood discharge between menstruation. But after three months of administration everything should be normalized after the body gets used to the action of the drug.

Logest doctor reviews

Reliable contraceptive

This drug belongs to reliable modern oral contraceptives.

The mechanism of action of Logest is to prevent ovulation, increase the viscosity of the cervical mucus, which prevents the promotion of sperm, and this drug affects the endometrium, thereby preventing possible implantation.

With the right reception means very reliable. But, like all hormonal contraceptives, there is a fairly large list of contraindications and side effects, therefore, in no case should you start taking Logest yourself, without a doctor's prescription.

Before you begin, be sure to carefully read the information from the leaflet.

If you are not sure that you can comply with all the conditions for taking the drug, it is better to choose another method of contraception with the doctor.

Reliable contraceptive

This drug belongs to reliable modern oral contraceptives.

The mechanism of action of Logest is to prevent ovulation, increase the viscosity of the cervical mucus, which prevents the promotion of sperm, and this drug affects the endometrium, thereby preventing possible implantation.

With the right reception means very reliable. But, like all hormonal contraceptives, there is a fairly large list of contraindications and side effects, therefore, in no case should you start taking Logest yourself, without a doctor's prescription.

Before you start taking very carefully ozn

Logest

Logest is a low-dose monophasic combination drug with contraceptive effect. In its line of contraceptives of this group has long taken a stable place, proved to be a reliable drug.

The contraceptive effect of logest consists in a complex of pharmacological mechanisms, the main of which are thickening of cervical mucus, inhibition of follicle growth and suppression of ovulation. Gestodene, which is part of the drug, reduces the risk of intermenstrual bleeding at the beginning of the reception.

Thanks to scientific research, it has been established that this drug reduces the risk of oncological changes of the endometrium and ovaries, ovarian cystic formations and inflammatory diseases of the pelvic organs, and diseases of the mammary gland.

Logest copes well with the manifestation of premenstrual syndrome, disorders of the ovarian-menstrual cycle. Thus, logest not only prevents unwanted pregnancy, but also helps to minimize unwanted sensations, such as pain, abundant discharge of blood during menstruation, mood changes, reduces the risk of anemia, which is an important positive moment in the life of a modern woman. Side effects in clinical practice are quite rare.

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